Intravenous thrombolysis is not recommended in anticoagulated patients receiving direct oral anticoagulants (DOACs) and a recent intake within the last 48 hours in US and European guidelines. However, three observational studies now suggest safety of thrombolysis in patients with recent intake of DOACs, and thus support previous experimental data. In this perspective, the current evidence and practical consequences are discussed.

中文翻译：

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尽管直接口服抗凝药物仍可溶栓治疗缺血性卒中

美国和欧洲指南不建议接受直接口服抗凝剂 (DOAC) 且最近 48 小时内服用过抗凝药物的患者进行静脉溶栓。然而，三项观察性研究现在表明近期服用 DOAC 的患者溶栓是安全的，从而支持了之前的实验数据。从这个角度来看，讨论了当前的证据和实际后果。