Abstract

Previously unknown phenyl-substituted iodo-δ-lactone derived from 11‑phenylundeca-5Z,9Z-dienoic acid was synthesized in 94% yield using the Ti-catalyzed intermolecular cross-cyclomagnesiation of aromatic 1,2-diene with O‑containing allene at the key stage. The in vitro cytotoxic activity of synthesized alkyl- and phenyl-substituted iodo-δ-lactones of 5Z,9Z-dienoic acids against the Jurkat, K562, U937, HL60, and Hek293 cell lines was studied, and their effect on the cell cycle and the ability to induce apoptosis were investigated using flow cytometry.

中文翻译：

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5Z,9Z-二烯酸碘-δ-内酯体外抗肿瘤活性研究

摘要

使用 Ti 催化的芳香族 1,2-二烯与含 O 的分子间交叉环镁化合成了以前未知的源自 11-苯基十一碳-5 Z ,9 Z -二烯酸的苯基取代的碘-δ-内酯，收率达 94%关键阶段的艾伦。研究了合成的5Z,9Z-二烯酸的烷基和苯基取代的碘代-δ-内酯对Jurkat、K562、U937、HL60和Hek293细胞系的体外细胞毒活性，及其对细胞的影响使用流式细胞术研究周期和诱导细胞凋亡的能力。