Intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) possess low sequence complexity of amino acids and display non-globular tertiary structures. They can act as scaffolds, form regulatory hubs, or trigger bimolecular condensation to control diverse aspects of biology. Emerging evidence has recently implicated critical roles of IDPs and IDR-contained proteins in nuclear transcription and cytoplasmic post-transcriptional processes, among other molecular functions. We here summarize the concepts and organizing principles of IDPs. We then illustrate recent progress in understanding the roles of key IDPs in machineries that regulate transcriptional and post-transcriptional gene silencing (PTGS) in plants, aiming at highlighting new modes of action of IDPs in controlling biological processes.

中文翻译：

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本质上无序的蛋白质如何控制植物基因沉默

本质无序蛋白质（IDP）和具有本质无序区域（IDR）的蛋白质具有较低的氨基酸序列复杂性并显示非球状三级结构。它们可以充当支架、形成调节中心或触发双分子缩合以控制生物学的各个方面。最近出现的证据表明，IDP 和包含 IDR 的蛋白质在核转录和细胞质转录后过程以及其他分子功能中发挥着关键作用。我们在这里总结一下国内流离失所者的概念和组织原则。然后，我们阐述了了解植物转录和转录后基因沉默（PTGS）机制中关键 IDP 的作用的最新进展，旨在强调 IDP 在控制生物过程中的新作用模式。