The ongoing trend of rapid aging of the global population has unavoidably resulted in an increase in aging-related diseases. There is an immense amount of interest in the scientific community for the identification of molecular targets that may effectively mitigate the process of aging and aging-related diseases. The enzyme Topoisomerase IIβ (TOP2B) plays a crucial role in resolving the topological challenges that occur during DNA-related processes. It is believed that the disruption of TOP2B function contributes to the aging of cells and tissues, as well as the development of age-related diseases. Consequently, targeting TOP2B appears to be a promising approach for interventions aimed at mitigating the effects of aging. This review focuses on recent advancements in the understanding of the role of TOP2B in the processing of aging and aging-related disorders, thus providing a novel avenue for the development of anti-aging strategies.

全球人口快速老龄化的持续趋势不可避免地导致与衰老相关的疾病增加。科学界对识别可以有效减轻衰老过程和衰老相关疾病的分子靶点抱有极大的兴趣。拓扑异构酶IIβ (TOP2B) 在解决 DNA 相关过程中出现的拓扑挑战方面发挥着至关重要的作用。据认为，TOP2B 功能的破坏会导致细胞和组织的衰老以及与年龄相关的疾病的发展。因此，针对 TOP2B 似乎是旨在减轻衰老影响的干预措施的一种有前途的方法。本综述重点介绍了 TOP2B 在衰老和衰老相关疾病处理中的作用的最新进展，从而为抗衰老策略的开发提供了新的途径。