Beta-Parvin (PARVB) is an actin-binding protein with functionality in extracellular matrix binding. Recent studies suggest its potential as a biomarker for various cancers, given its role in governing several malignancies. Yet, its involvement and modulatory mechanisms in malignant melanoma remain under-explored. In this research, we undertook a comprehensive pan-cancer analysis centered on PARVB. We probed its aberrant expression and prognostic implications, and assessed correlations between PARVB expression and immunocyte infiltration. This expression was subsequently corroborated using clinical samples. Both and , we discerned the functional ramifications of PARVB on melanoma. Furthermore, we scrutinized how HIF-1α/2α modulates PARVB and initiated a preliminary investigation into potential downstream pathways influenced by PARVB. Our results illuminate that elevated PARVB expression manifests across various tumors and significantly influences the prognosis of multiple cancers, emphasizing its peculiar expression and prognostic relevance in melanoma. Augmented PARVB levels were inversely proportional to immunocyte penetration in melanoma. Silencing PARVB curtailed cellular proliferation, migration, and invasion and decelerated tumor expansion . Notably, hypoxic conditions, triggering HIF-1α/2α activation, appear to elevate PARVB expression by anchoring to the hypoxia-specific responsive element within the PARVB promoter. Enhanced PARVB levels seem intertwined with the activation of cellular proliferation circuits and the damping of inflammatory trajectories. Collectively, these revelations posit PARVB as a potential prognostic indicator and therapeutic linchpin for malignant melanoma.

中文翻译：

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PARVB 促进恶性黑色素瘤进展，并因缺氧条件而增强

Beta-Parvin (PARVB) 是一种肌动蛋白结合蛋白，具有细胞外基质结合功能。最近的研究表明，鉴于其在控制多种恶性肿瘤中的作用，它有可能作为各种癌症的生物标志物。然而，其在恶性黑色素瘤中的参与和调节机制仍未得到充分探索。在本研究中，我们以PARVB为中心进行了全面的泛癌分析。我们探讨了其异常表达和预后意义，并评估了 PARVB 表达和免疫细胞浸润之间的相关性。随后使用临床样本证实了这种表达。和 ，我们识别了 PARVB 对黑色素瘤的功能影响。此外，我们仔细研究了 HIF-1α/2α 如何调节 PARVB，并对受 PARVB 影响的潜在下游途径启动了初步研究。我们的结果表明，PARVB 表达升高在多种肿瘤中均有表现，并显着影响多种癌症的预后，强调了其在黑色素瘤中的特殊表达和预后相关性。黑色素瘤中 PARVB 水平升高与免疫细胞渗透成反比。沉默 PARVB 可减少细胞增殖、迁移和侵袭，并减缓肿瘤扩张。值得注意的是，缺氧条件触发 HIF-1α/2α 激活，似乎通过锚定到 PARVB 启动子内的缺氧特异性反应元件来提高 PARVB 表达。PARVB 水平的升高似乎与细胞增殖回路的激活和炎症轨迹的抑制交织在一起。总的来说，这些发现将 PARVB 视为恶性黑色素瘤的潜在预后指标和治疗关键。