Ovarian cancer is a prevalent gynecological malignancy associated with a high mortality rate and a low 5‑year survival rate. Typically, >70% of patients present with an advanced stage of the disease, resulting in a high number of ovarian cancer‑associated deaths worldwide. Over the past decade, adoptive cellular immunotherapy has been investigated in clinical trials, and the results have led to the increased use in cancer treatment. Natural killer (NK) cells are cytotoxic lymphoid cells that recognize and lyse transformed cells, thereby impeding tumor growth. Thus, NK cells exhibit potential as a form of immunotherapy in the treatment of cancer. However, some patients with ovarian cancer treated with NK cells have experienced unsatisfactory outcomes. Therefore, further optimization of NK cells is required to increase the number of patients achieving long‑term remission. In the present review article, studies focusing on improving NK cell function were systematically summarized, and innovative strategies that augment the anticancer properties of NK cells were proposed.

中文翻译：

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增强 NK 细胞治疗卵巢癌的疗效（综述）。

卵巢癌是一种常见的妇科恶性肿瘤，死亡率高，5 年生存率低。通常，超过 70% 的患者已处于疾病晚期，导致全世界卵巢癌相关死亡人数很高。在过去的十年中，过继性细胞免疫疗法已在临床试验中进行了研究，其结果导致其在癌症治疗中的应用不断增加。自然杀伤 (NK) 细胞是细胞毒性淋巴细胞，可识别并裂解转化细胞，从而阻止肿瘤生长。因此，NK 细胞显示出作为癌症治疗中免疫疗法的一种形式的潜力。然而，一些接受 NK 细胞治疗的卵巢癌患者的结果并不令人满意。因此，需要进一步优化 NK 细胞，以增加实现长期缓解的患者数量。在本综述文章中，系统总结了专注于改善 NK 细胞功能的研究，并提出了增强 NK 细胞抗癌特性的创新策略。