Lynch syndrome (LS) increases the risk of numerous different cancers including gastric cancer. While some current guidelines recommend empiric gastric biopsies be performed during upper gastrointestinal cancer surveillance in Lynch syndrome (LS), the yield of these biopsies and the prevalence of gastric intestinal metaplasia (GIM) and Helicobacter pylori (HP) in LS remains unknown. Herein we analyze 165 consecutive individuals with LS who underwent upper endoscopic surveillance with biopsies of the gastric antrum and body being performed universally in all individuals. Of the study cohort, 6.7% of universally biopsied individuals with LS had GIM and/or HP (5.5% GIM, 3.6% HP). Biopsies of the gastric body did not increase rates of GIM/HP identification compared to antral biopsies alone. GIM was detected on subsequent surveillance in 2.2% of individuals without prior GIM, which may represent either newly developed GIM or GIM that was missed on a prior upper endoscopy due to sampling error. These findings support inclusion of at least baseline gastric antrum biopsies as a routine component of all standard surveillance upper endoscopies performed in LS.

林奇综合征 (LS) 会增加多种不同癌症的风险，包括胃癌。虽然目前的一些指南建议在林奇综合征 (LS) 的上消化道癌症监测期间进行经验性胃活检，但这些活检的产量以及 LS 中胃肠化生 (GIM) 和幽门螺杆菌(HP) 的患病率仍然未知。在此，我们分析了连续 165 名 LS 患者，这些患者接受了上消化道内镜监测，并对所有个体进行了胃窦和胃体活检。在研究队列中，6.7% 接受普遍活检的 LS 患者患有 GIM 和/或 HP（5.5% GIM，3.6% HP）。与单独的胃窦活检相比，胃体活检并没有增加 GIM/HP 的识别率。在随后的监测中，2.2% 的先前没有 GIM 的个体检测到了 GIM，这可能代表新开发的 GIM 或由于采样误差而在之前的上消化道内窥镜检查中漏掉的 GIM。这些发现支持至少将基线胃窦活检作为 LS 中进行的所有标准监测上消化道内窥镜检查的常规组成部分。