Early-stage diagnosis of breast cancer is critical for effective treatment and the best potential survival rates. Biosensors have evolved as a smart screening tool for identifying biomarkers associated with breast cancer initiation, progression, and treatment. In this work, a dielectric modulated dopingless dual metal gate heterojunction Tunnel Field Effect Transistor (DM-DL-DMG-HJTFET) is proposed for the detection of breast cancer cell lines which has a nanogap beneath the gate electrode towards source side where the breast cells will be immobilized. Healthy and cancerous breast cells are reported to possess different dielectric properties which result in different conductivity and hence can help in early breast cancer detection. The proposed biosensor is simulated using SILVACO ATLAS TCAD tool and the calibrated results are used for the in-depth analysis of energy band diagram, electric field, and surface potential. Practical functionality is studied by incorporating different cases of partially and non-uniformly filled cavity along with mixed cell proportions in the cavity. Sensitivity of the proposed biosensor has been found in terms of drain current, threshold voltage, transconductance, and ratio. The proposed structure offers significant improvement in the sensitivity as seen from the comparative performance analysis and hence can be used to establish a point-of-care (POC) diagnosis setting.

中文翻译：

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考虑非理想杂交问题，使用无掺杂异质结 TFET 对乳腺癌细胞系进行无标记检测

乳腺癌的早期诊断对于有效治疗和最佳潜在生存率至关重要。生物传感器已发展成为一种智能筛查工具，用于识别与乳腺癌发生、进展和治疗相关的生物标志物。在这项工作中，提出了一种介电调制无掺杂双金属栅极异质结隧道场效应晶体管（DM-DL-DMG-HJTFET）用于检测乳腺癌细胞系，该细胞系在栅极电极下方朝向源极侧有一个纳米间隙，其中乳腺细胞将会被固定住。据报道，健康和癌性乳腺细胞具有不同的介电特性，从而导致不同的电导率，因此有助于早期乳腺癌检测。使用SILVACO ATLAS TCAD工具对所提出的生物传感器进行模拟，并将校准结果用于能带图、电场和表面电位的深入分析。通过结合部分和不均匀填充空腔的不同情况以及空腔中的混合单元比例来研究实际功能。所提出的生物传感器的灵敏度通过漏极电流、阈值电压、跨导和比率来确定。从比较性能分析中可以看出，所提出的结构显着提高了灵敏度，因此可用于建立即时护理 (POC) 诊断设置。