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Unraveling the brain’s response to COVID-19: How SARS-CoV-2 afflicts dopaminergic neurons
Cell Stem Cell ( IF 23.9 ) Pub Date : 2024-02-01 , DOI: 10.1016/j.stem.2024.01.002
Ilse Eidhof , Daniel Twohig , Anna Falk

COVID-19 patients often display dysfunctions of the nervous system, indicating an effect of SARS-CoV-2 on neural cells. Yang et al. now show that human stem-cell-derived dopaminergic neurons are susceptible to SARS-CoV-2, triggering inflammation and senescence. The study further identifies three FDA-approved drugs capable of reversing these cellular phenotypes.



中文翻译:

揭示大脑对 COVID-19 的反应:SARS-CoV-2 如何影响多巴胺能神经元

COVID-19 患者经常表现出神经系统功能障碍,表明 SARS-CoV-2 对神经细胞有影响。杨等人。现在表明,人类干细胞来源的多巴胺能神经元容易受到 SARS-CoV-2 的影响,从而引发炎症和衰老。该研究进一步确定了 FDA 批准的三种能够逆转这些细胞表型的药物。

更新日期:2024-02-01
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