Non-alcoholic fatty liver disease (NAFLD) is a global metabolic disease with high prevalence in both adults and children. Importantly, NAFLD is becoming the main cause of hepatocellular carcinoma (HCC). Berberine (BBR), a naturally occurring plant component, has been demonstrated to have advantageous effects on a number of metabolic pathways as well as the ability to kill liver tumor cells by causing cell death and other routes. This permits us to speculate and make assumptions about the value of BBR in the prevention and defense against NAFLD and HCC by a global modulation of metabolic disorders. Herein, we briefly describe the etiology of NAFLD and NAFLD-related HCC, with a particular emphasis on analyzing the potential mechanisms of BBR in the treatment of NAFLD from aspects including increasing insulin sensitivity, controlling the intestinal milieu, and controlling lipid metabolism. We also elucidate the mechanism of BBR in the treatment of HCC. More significantly, we provided a list of clinical studies for BBR in NAFLD. Taking into account our conclusions and perspectives, we can make further progress in the treatment of BBR in NAFLD and NAFLD-related HCC.

中文翻译：

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小檗碱通过调节代谢紊乱预防 NAFLD 和 HCC

非酒精性脂肪肝（NAFLD）是一种全球性代谢性疾病，在成人和儿童中患病率很高。重要的是，NAFLD 正在成为肝细胞癌 (HCC) 的主要原因。小檗碱 (BBR) 是一种天然存在的植物成分，已被证明对许多代谢途径具有有利影响，并且能够通过引起细胞死亡和其他途径杀死肝肿瘤细胞。这使我们能够推测和假设 BBR 通过全局调节代谢紊乱来预防和防御 NAFLD 和 HCC 的价值。在此，我们简要描述NAFLD和NAFLD相关HCC的病因，重点从增加胰岛素敏感性、控制肠道环境、控制脂质代谢等方面分析BBR治疗NAFLD的潜在机制。我们还阐明了 BBR 治疗 HCC 的机制。更重要的是，我们提供了 BBR 在 NAFLD 中的临床研究列表。考虑到我们的结论和观点，我们可以在 BBR 治疗 NAFLD 和 NAFLD 相关 HCC 方面取得进一步进展。