Abstract

Hibiscus species are flowering plants of the Malvaceae family. Hibiscus are widely distributed in tropical and subtropical regions and play an important role not only in ornamental aspects but also traditional medicine. In this study, seven compounds, mukungarrole (1), a new compound and six known flavonoid derivatives (2–7) were isolated from Hibiscus syriacus pollen. Among the isolated compounds, kaempferol (2) and vincetoxicoside B (3) showed antioxidant activity. Additonally, the new compound, mukungarrole (1), along with kaempferol (2) and isorhamnetin-7-O-rhamnoside (5), showed α-glucosidase inhibitory activity and its interaction with α-glucosidase was confirmed using molecular docking analysis. Further comparison of five varieties of Hibiscus spp. showed that all five species contained vincetoxicoside B (3) and kaempferol-7-O-rhamnoside (4) as major components and exhibited antioxidant and α-glucosidase inhibitory activities. However, there was differences in the content of vincetoxicoside B (3) and kaempferol-7-O-rhamnoside (4) and minor components depending on of Hibiscus variety, which contributed to differences in efficacy. This study proves that H. syriacus pollen and its constituents have antioxidant and α-glucosidase inhibitory potentials and the content and efficacy vary depending on Hibiscus species.

中文翻译：

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木槿花粉的抗氧化和 α-葡萄糖苷酶抑制潜力。

摘要

木槿属是锦葵科的开花植物。木槿广泛分布于热带和亚热带地区，不仅在观赏方面发挥着重要作用，而且在传统医学方面也发挥着重要作用。在这项研究中，从木槿花粉中分离出了七种化合物，即一种新化合物Mukungarrole ( 1 ) 和六种已知的黄酮衍生物 ( 2 – 7 ) 。在分离的化合物中，山奈酚 ( 2 ) 和长春毒苷 B ( 3 ) 显示出抗氧化活性。此外，新化合物 mukungarrole ( 1 ) 与山奈酚 ( 2 ) 和 isorhamnetin-7- O -rhamnoside ( 5 ) 一起显示出 α-葡萄糖苷酶抑制活性，并且通过分子对接分析证实了其与 α-葡萄糖苷酶的相互作用。木槿属五个品种的进一步比较。结果表明，所有 5 个物种均含有长春毒苷 B ( 3 ) 和山奈酚-7- O-鼠李糖苷 ( 4 ) 作为主要成分，并表现出抗氧化和 α-葡萄糖苷酶抑制活性。然而，根据木槿品种的不同，长春毒苷B ( 3 ) 和山奈酚-7- O-鼠李糖苷( 4 ) 以及微量成分的含量存在差异，这导致了功效的差异。这项研究证明，木槿花粉及其成分具有抗氧化和α-葡萄糖苷酶抑制潜力，且其含量和功效因木槿属品种而异。