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Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions
Chinese Journal of Polymer Science ( IF 4.3 ) Pub Date : 2024-01-25 , DOI: 10.1007/s10118-024-3081-0
Tatiana N. Nekrasova , Andrei I. Fischer , Natalia A. Nesterova , Anatoliy V. Dobrodumov , Anzhelika V. Garshinina , Olga D. Shuvaeva , Natalya V. Zakharova , Evgenii F. Panarin

Water-soluble copolymers of p-methacrylamidobenzoic acid (MABA) with neutral comonomers (N-vinylpyrrolidone (VP), N-methyl-N-vinylacetamide (MVAA), N-methacryloyl glucosamine (MAG)) and anionic comononer sodium styrene sulfonate (NaSS) were synthesized by radical copolymerization. The interactions between the prepared copolymers and Tb3+ ions in aqueous solutions were studied; the significant influence of chemical structure of a comonomer on luminescence intensity of Tb3+ complexes with the copolymers was revealed. The luminescence intensity of Tb3+ complexes with the copolymers containing N-vinylamide units (VP, MVAA) is three times more intense than that observed for the complexes between Tb3+ and MAG-containing copolymers. In the case of NaSS-containing copolymers, the luminescence intensity is controlled by the values of binding constants between Tb3+ and MABA and the content of MABA units in a copolymer. The studied copolymers and their complexes with Tb3+ have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.



中文翻译:

生物活性高分子配体及其铽离子发光配合物的设计

对甲基丙烯酰氨基苯甲酸 (MABA) 与中性共聚单体(N-乙烯基吡咯烷酮 (VP)、N-甲基-N-乙烯基乙酰胺 (MVAA)、N-甲基丙烯酰氨基苯甲酸 (MAG))和阴离子共聚单体苯乙烯磺酸钠 (NaSS) 的水溶性共聚物)通过自由基共聚合成。研究了所制备的共聚物与水溶液中Tb 3+离子的相互作用;揭示了共聚单体的化学结构对Tb 3+与共聚物的配合物的发光强度的显着影响。 Tb 3+与含有N-乙烯基酰胺单元(VP、MVAA)的共聚物的配合物的发光强度是Tb 3+与含有MAG的共聚物之间的配合物的发光强度的三倍。在含NaSS的共聚物的情况下,发光强度由Tb 3+和MABA之间的结合常数值以及共聚物中MABA单元的含量控制。所研究的共聚物及其与Tb 3+的复合物具有低细胞毒性和对人呼吸道合胞病毒的显着抗病毒活性。

更新日期:2024-01-25
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