Members of the genus are the causative agents of brucellosis, a worldwide zoonosis affecting wild and domestic animals and humans. These facultative intracellular pathogens cause long-lasting chronic infections by evolving sophisticated strategies to counteract, evade, or subvert host bactericidal mechanisms in order to establish a secure replicative niche necessary for their survival. In this review, we present recent findings on selected effectors to illustrate how this pathogen modulates host cell signaling pathways to gain control of the vacuole, promote the formation of a safe intracellular replication niche, alter host cell metabolism to its advantage, and exploit various cellular pathways to ensure egress from the infected cell.

中文翻译：

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布鲁氏菌细胞内旅程的“来龙去脉”

该属的成员是布鲁氏菌病的病原体，布鲁氏菌病是一种影响野生、家养动物和人类的世界性人畜共患病。这些兼性细胞内病原体通过进化出复杂的策略来抵消、逃避或颠覆宿主的杀菌机制，从而建立其生存所需的安全复制生态位，从而引起持久的慢性感染。在这篇综述中，我们介绍了选定效应子的最新发现，以说明这种病原体如何调节宿主细胞信号传导途径以获得对液泡的控制，促进安全的细胞内复制生态位的形成，改变宿主细胞代谢以使其有利，并利用各种细胞确保从受感染细胞中流出的途径。