More and more evidence shows that long non-coding RNA (lncRNA) plays an important role in the biological behavior of many kinds of malignant tumors, but the specific function of lncRNA in cervical cancer is still unknown. The purpose of this study is to explore the effect of on the malignant progression of cervical cancer and its potential mechanism. In two kinds of cervical cancer cell lines and normal cervical epithelial cells, qRT-PCR showed increased expression of in cervical cancer cells. Through MTT, clone formation test, flow cytometry, wound healing test and Transwell test, it has been found that overexpression of could promote the proliferation,migration and invasion of cervical cancer cells，and inhibit apoptosis. Through the StarBase database, it was found that there may be a mutual regulatory relationship between and , and may be the downstream target of . QRT-PCR detection confirmed that the expression of was increased in cervical cancer cells with overexpression of . TIMER2 database found that was associated with lipid metabolic enzymes and immune cell infiltration. It was found that knockdown inhibited tumor growth and metastasis and inhibited the expression of . In short, our research shows that has carcinogenic properties in cervical cancer, and promotes the occurrence of cervical cancer by up-regulating the expression of . We predict that // axis plays a role in the malignant progression of cervical cancer. In addition, may participate in cancer immune response and promote lymph node metastasis of cervical cancer through lipid reprogramming. These findings also provide promising targets for the diagnosis and treatment of cervical cancer.

中文翻译：

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长非编码RNA Linc00657上调Skp2通过脂质重编程和免疫微环境调节促进宫颈癌进展

越来越多的证据表明，长链非编码RNA（lncRNA）在多种恶性肿瘤的生物学行为中发挥着重要作用，但lncRNA在宫颈癌中的具体功能仍不清楚。本研究的目的是探讨其对宫颈癌恶性进展的影响及其潜在机制。在两种宫颈癌细胞系和正常宫颈上皮细胞中，qRT-PCR显示宫颈癌细胞中的表达增加。通过MTT、克隆形成实验、流式细胞术、创面愈合实验和Transwell实验发现，过表达能够促进宫颈癌细胞的增殖、迁移和侵袭，并抑制细胞凋亡。通过StarBase数据库发现， 和 之间可能存在相互监管关系，并且可能是 的下游目标。QRT-PCR检测证实，过度表达的宫颈癌细胞中，表达增加。TIMER2数据库发现这与脂质代谢酶和免疫细胞浸润有关。研究发现，敲低可抑制肿瘤生长和转移，并抑制 的表达。总之，我们的研究表明，在宫颈癌中具有致癌特性，并通过上调 的表达促进宫颈癌的发生。我们预测 // 轴在宫颈癌的恶性进展中发挥作用。此外，可能通过脂质重编程参与癌症免疫反应并促进宫颈癌的淋巴结转移。这些发现也为宫颈癌的诊断和治疗提供了有希望的目标。