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Large-scale proteomics in the first trimester of pregnancy predict psychopathology and temperament in preschool children: an exploratory study
Journal of Child Psychology and Psychiatry ( IF 7.6 ) Pub Date : 2024-01-29 , DOI: 10.1111/jcpp.13948
Jessica L. Buthmann 1 , Jonas G. Miller 2 , Nima Aghaeepour 3, 4, 5 , Lucy S. King 1 , David K. Stevenson 3 , Gary M. Shaw 3 , Ronald J. Wong 3 , Ian H. Gotlib 1
Affiliation  

Understanding the prenatal origins of children's psychopathology is a fundamental goal in developmental and clinical science. Recent research suggests that inflammation during pregnancy can trigger a cascade of fetal programming changes that contribute to vulnerability for the emergence of psychopathology. Most studies, however, have focused on a handful of proinflammatory cytokines and have not explored a range of prenatal biological pathways that may be involved in increasing postnatal risk for emotional and behavioral difficulties.

中文翻译:

怀孕前三个月的大规模蛋白质组学预测学龄前儿童的精神病理学和气质:一项探索性研究

了解儿童精神病理学的产前起源是发展和临床科学的基本目标。最近的研究表明,怀孕期间的炎症可能会引发一系列胎儿编程变化,从而导致精神病理学的出现。然而,大多数研究都集中在少数促炎细胞因子上,并没有探索一系列可能与增加产后情绪和行为困难风险有关的产前生物学途径。
更新日期:2024-02-02
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