Microbial contamination poses a serious threat to human life and health. Through the intersection of material science and modern medicine, advanced bionic hydrogels have shown great potential for biomedical applications due to their unique bioactivity and ability to mimic the extracellular matrix environment. In particular, as a promising antimicrobial material, the synthesis and practical biomedical applications of peptide-based antimicrobial hydrogels have drawn increasing research interest. The synergistic effect of peptides and hydrogels facilitate the controlled release of antimicrobial agents and mitigation of their biotoxicity while achieving antimicrobial effects and protecting the active agents from degradation. This review reports on the progress and trends of researches in the last five years and provides a brief outlook, aiming to provide theoretical background on peptide-based antimicrobial hydrogels and make suggestions for future related work.

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肽基抗菌水凝胶的开发及生物医学应用现状

微生物污染对人类生命和健康构成严重威胁。通过材料科学和现代医学的交叉，先进的仿生水凝胶由于其独特的生物活性和模拟细胞外基质环境的能力，在生物医学应用中显示出巨大的潜力。特别是，作为一种有前途的抗菌材料，基于肽的抗菌水凝胶的合成和实际生物医学应用引起了越来越多的研究兴趣。肽和水凝胶的协同作用有助于控制抗菌剂的释放并减轻其生物毒性，同时实现抗菌效果并保护活性剂免遭降解。本文综述了近五年来的研究进展和趋势，并进行了简要展望，旨在为肽基抗菌水凝胶的研究提供理论背景，并为今后的相关工作提出建议。