High resolution mass spectrometry (HRMS) has become an important tool in environmental and food safety analysis. This review highlights how HRMS has been used to analyze chemical contaminants in fish. Measuring and documenting chemical contaminants in fish serves not only as an indicator of environmental conditions but can also monitor the health of these animals and help protect an important source of human food. The incidence and significance of contaminants including veterinary drugs, human drugs and personal care products, pesticides, persistent organic pollutants, per- and poly fluorinated substances, and marine toxins will be reviewed. The advantage of HRMS over traditional MS is its ability to expand the number of compounds that can be detected and identified. This is true whether HRMS is used for targeted analytes, or more broadly for suspect screening and nontargeted analyses. The classes of compounds, types of fish or seafood, options for data acquisition and analysis, and reports of unexpected findings from recent HMRS methods for chemical contaminants in fish are summarized.

中文翻译：

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使用高分辨率质谱分析鱼类中的化学污染物 – 综述

高分辨率质谱（HRMS）已成为环境和食品安全分析的重要工具。本综述重点介绍了如何使用 HRMS 来分析鱼类中的化学污染物。测量和记录鱼类中的化学污染物不仅可以作为环境条件的指标，还可以监测这些动物的健康并帮助保护人类食物的重要来源。将审查包括兽药、人类药物和个人护理产品、农药、持久性有机污染物、全氟化物和多氟化物以及海洋毒素在内的污染物的发生率和重要性。HRMS 相对于传统 MS 的优势在于它能够扩大可检测和识别的化合物数量。无论 HRMS 是用于目标分析物，还是更广泛地用于可疑筛查和非目标分析，都是如此。总结了化合物的类别、鱼类或海鲜的类型、数据采集和分析的选项，以及最近 HMRS 方法对鱼类化学污染物的意外发现的报告。