Dengue hemorrhagic fever (DHF) is a severe condition resulting from the dengue virus, with four serotypes known as DEN-1, DEN-2, DEN-3, and DEN-4. Genetic variations play a crucial role in influencing susceptibility to DHF. Therefore, this investigation conducted a meta-analysis to uncover genetic changes that might have remained undetected in individual studies due to small sample sizes or methodological differences. Among 2212 initially identified studies, 23 were deemed suitable for analysis based on PRISMA guidelines. Toll-like receptors (TLR) and CD209 showed significant association with DHF (odds ratios: TLR=0.56, CD209 =0.55), indicating protective effects. However, tumor necrosis factor (TNF) and human leukocyte antigen (HLA) did not exhibit a statistically significant relationship with DHF. This study emphasizes the relevance of TLR and CD209 in DHF susceptibility and resistance across diverse geographical locations.

中文翻译：

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与登革出血热相关的遗传变异。系统回顾和荟萃分析

登革出血热 (DHF) 是由登革热病毒引起的严重疾病，有四种血清型，分别为 DEN-1、DEN-2、DEN-3 和 DEN-4。遗传变异在影响 DHF 易感性方面发挥着至关重要的作用。因此，本研究进行了荟萃分析，以揭示由于样本量小或方法学差异而在个别研究中可能未被检测到的基因变化。在 2212 项最初确定的研究中，有 23 项被认为适合根据 PRISMA 指南进行分析。 Toll 样受体 (TLR) 和 CD209 显示与 DHF 显着相关（优势比：TLR=0.56，CD209=0.55），表明具有保护作用。然而，肿瘤坏死因子（TNF）和人类白细胞抗原（HLA）与DHF没有表现出统计学上显着的关系。这项研究强调了 TLR 和 CD209 在不同地理位置的 DHF 易感性和耐药性中的相关性。