The field of cancer genomics and transcriptomics has evolved from targeted profiling to swift sequencing of individual tumor genome and transcriptome. The steady growth in genome, epigenome, and transcriptome datasets on a genome-wide scale has significantly increased our capability in capturing signatures that represent both the intrinsic and extrinsic biological features of tumors. These biological differences can help in precise molecular subtyping of cancer, predicting tumor progression, metastatic potential, and resistance to therapeutic agents. In this review, we summarized the current development of genomic, methylomic, transcriptomic, proteomic and metabolic signatures in the field of cancer research and highlighted their potentials in clinical applications to improve diagnosis, prognosis, and treatment decision in cancer patients.

中文翻译：

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癌症组学特征的发展和翻译趋势综述

癌症基因组学和转录组学领域已经从靶向分析发展到单个肿瘤基因组和转录组的快速测序。全基因组范围内的基因组、表观基因组和转录组数据集的稳定增长显着提高了我们捕获代表肿瘤内在和外在生物学特征的特征的能力。这些生物学差异有助于对癌症进行精确的分子分型，预测肿瘤进展、转移潜力和对治疗药物的耐药性。在这篇综述中，我们总结了癌症研究领域基因组、甲基组学、转录组学、蛋白质组学和代谢特征的当前发展，并强调了它们在临床应用中改善癌症患者的诊断、预后和治疗决策的潜力。