Purpose

This paper aims to study the feasibility of proposed method to focus the electroporation ablation by mean of multi-output multi-electrode system.

Design/methodology/approach

The proposed method has been developed based on a previously designed electroporation system, which has the capabilities to modify the electric field distribution in real time, and to estimate the impedance distribution. Taking into consideration the features of the system and biological tissues, the problem has been addressed in three phases: modeling, control system design and simulation testing. In the first phase, a finite element analysis model has been proposed to reproduce the electric field distribution within the hepatic tissue, based on the characteristics of the electroporation system. Then, a control strategy has been proposed with the goal of ensuring complete ablation while minimizing the affected volume of healthy tissue. Finally, to check the feasibility of the proposal, several representative cases have been simulated, and the results have been compared with those obtained by a traditional system.

Findings

The proposed method achieves the proposed goal, as part of a complex electroporation system designed to improve the targeting, effectiveness and control of electroporation treatments and serve to demonstrate the feasibility of developing new electroporation systems capable of adapting to changes in the preplanning of the treatment in real-time.

Originality/value

The work presents a thorough study of control method to multi-output multi-electrode electroporation system by mean of a rigorous numerical simulation.

中文翻译：

---

使用多电极结构和生物医学多输出发生器优化IRE靶向

目的

本文旨在研究所提出的多输出多电极系统聚焦电穿孔消融方法的可行性。

设计/方法论/途径

该方法是基于先前设计的电穿孔系统开发的，该系统能够实时修改电场分布并估计阻抗分布。考虑到系统和生物组织的特点，问题分为建模、控制系统设计和仿真测试三个阶段来解决。在第一阶段，根据电穿孔系统的特性，提出了有限元分析模型来重现肝组织内的电场分布。然后，提出了一种控制策略，其目标是确保完全消融，同时最大限度地减少健康组织受影响的体积。最后，为了检验该建议的可行性，对几个代表性案例进行了模拟，并将结果与​​传统系统获得的结果进行了比较。

发现

所提出的方法实现了所提出的目标，作为复杂电穿孔系统的一部分，旨在提高电穿孔治疗的靶向性、有效性和控制，并证明开发能够适应治疗预先计划变化的新型电穿孔系统的可行性。即时的。

原创性/价值

该工作通过严格的数值模拟对多输出多电极电穿孔系统的控制方法进行了深入研究。