To test the protective effects of and curcumin on the ganglion tissues of diabetic rats following the use of autologous vein graft in peripheral nerve transection injury. The sciatic nerve on the right side was transected, and anastomosis was performed between the proximal and distal ends using an autologous vein graft. Curcumin and seed extract were administered daily by oral gavage. The ganglion tissues were harvested after a 90-day waiting period. Sensory neurons in the dorsal root ganglion at the L4 and L5 levels were used for stereological evaluations. Mean sensory neuron numbers were analyzed using a stereological technique. The size of the light and dark neurons was also estimated, and ultrastructural and immunohistochemical evaluations were performed. A statistically significant difference in sensory neuron numbers was observed between the groups with and without and curcumin applications. The immunohistochemical results showed that the s-100 protein is expressed selectively between cell types. The results of this study show that curcumin and prevented sensory neuron loss in diabetic rats following transection injury to the sciatic nerve.

中文翻译：

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藤黄果和姜黄素对糖尿病大鼠周围神经横断损伤后背根神经节的影响

探讨姜黄素和姜黄素对糖尿病大鼠自体静脉移植周围神经横断损伤后神经节组织的保护作用。横断右侧坐骨神经，使用自体静脉移植物在近端和远端之间进行吻合。每天通过口服管饲法施用姜黄素和种子提取物。经过 90 天的等待期后收获神经节组织。 L4 和 L5 水平的背根神经节中的感觉神经元用于体视学评估。使用体视学技术分析平均感觉神经元数量。还估计了亮神经元和暗神经元的大小，并进行了超微结构和免疫组织化学评估。在使用和不使用姜黄素的组之间观察到感觉神经元数量存在统计学上的显着差异。免疫组化结果表明s-100蛋白在细胞类型之间选择性表达。这项研究的结果表明，姜黄素可以防止糖尿病大鼠坐骨神经横断损伤后的感觉神经元损失。