Metformin is an anti-diabetic drug. Metformin mainly inhibits gluconeogenesis in the liver and reduces blood sugar. In addition to the anti-diabetic effects, many studies have revealed that metformin has anti-inflammatory effects. Various molecules were suggested to be the target of the metformin's anti-inflammatory effects. However, the conclusion is not clear. Metformin is related to a number of molecules and the identification of the main target in anti-inflammatory effects leads to the understanding of inflammation and metformin. In this article, I discuss each suggested molecule, involved mechanisms, and their relationship with various diseases.

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二甲双胍的抗炎作用：分子靶点

二甲双胍是一种抗糖尿病药物。二甲双胍主要抑制肝脏糖异生，降低血糖。除了抗糖尿病作用外，许多研究表明二甲双胍还具有抗炎作用。多种分子被认为是二甲双胍抗炎作用的靶点。但结论尚不明确。二甲双胍与许多分子有关，抗炎作用主要靶点的识别有助于对炎症和二甲双胍的了解。在这篇文章中，我讨论了每个建议的分子、涉及的机制以及它们与各种疾病的关系。