Bipolar depression is the major cause of morbidity in patients with bipolar disorder. It affects psychosocial functioning and markedly impairs occupational productivity. Anhedonia is one of the most debilitating symptoms of depression contributing to treatment resistance. It correlates with suicidality, low quality of life, social withdrawal, and poor treatment response. Currently, there is no approved treatment specifically targeting anhedonia. Emerging evidence suggests that ketamine possesses anti-anhedonic properties in individuals with depression.

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氯胺酮治疗双相抑郁症的快感缺失

双相抑郁是双相情感障碍患者发病的主要原因。它影响社会心理功能并显着损害职业生产力。快感缺乏是抑郁症最令人衰弱的症状之一，会导致治疗抵抗。它与自杀倾向、生活质量低下、社交退缩和治疗反应不佳有关。目前，还没有批准的专门针对快感缺乏的治疗方法。新的证据表明，氯胺酮对抑郁症患者具有抗快感缺乏的特性。