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Essential Oils of Some Potential Medicinal Plants and Their Wound Healing Activities
Current Pharmaceutical Biotechnology ( IF 2.8 ) Pub Date : 2024-02-04 , DOI: 10.2174/0113892010282605231218064053
Shiv Bahadur 1 , Sana Fatima 1
Affiliation  

: The wound has been recognised as a deep cut or tearing of the epidermis, which is also referred to as trauma and harm to the body tissues. Healing of wounds requires a coordinated series of cellular processes, including cell attraction, proliferation, differentiation, and angiogenesis. These processes involve interactions between various cells, such as macrophages, endothelial cells, keratinocytes, fibroblasts, growth hormones, and proteases. The outcome of wounds can be fatal if not treated properly, resulting in chronic wounds, chronic pain, and even death. Wound healing is replacing missing tissue with tissue repairs and regeneration. Some local variables are the presence of tissue maceration, foreign objects, biofilm, hypoxia, ischemia, and wound infection. Sustained growth factor delivery, siRNA delivery, micro-RNA targeting, and stem cell therapy are all emerging possible therapeutic approaches for wound healing. Traditional approaches, such as Ayurveda, Siddha, and Unani medicines, are also being used for treatment. The therapeutic application of nanoformulations in wound infections has shown various beneficial effects. Several herbal medicines, especially essential oils have shown potential wound healing activities, such as lavender, tea tree, sesame, olive, etc. Various nanoparticles and their nanoformulations have been explored in wound healing therapy. The present review article highlights several aspects of essential oils for wound healing activity through a novel drug delivery system. Further, some patents on wound healing through herbal medicine have been listed.

中文翻译:

一些潜在药用植物的精油及其伤口愈合活性

:伤口被认为是表皮的深度割伤或撕裂,也称为外伤和对身体组织的伤害。伤口愈合需要一系列协调的细胞过程,包括细胞吸引、增殖、分化和血管生成。这些过程涉及各种细胞之间的相互作用,例如巨噬细胞、内皮细胞、角质形成细胞、成纤维细胞、生长激素和蛋白酶。如果处理不当,伤口的后果可能是致命的,导致慢性伤口、慢性疼痛,甚至死亡。伤口愈合是通过组织修复和再生来替代缺失的组织。一些局部变量包括组织浸渍、异物、生物膜、缺氧、缺血和伤口感染的存在。持续生长因子递送、siRNA 递送、微小 RNA 靶向和干细胞治疗都是新兴的伤口愈合可能的治疗方法。阿育吠陀、Siddha 和 Unani 药物等传统方法也被用于治疗。纳米制剂在伤口感染中的治疗应用已显示出多种有益效果。几种草药,特别是精油已显示出潜在的伤口愈合活性,如薰衣草、茶树、芝麻、橄榄等。各种纳米颗粒及其纳米制剂已在伤口愈合治疗中进行了探索。本综述文章重点介绍了精油通过新型药物输送系统促进伤口愈合的几个方面。此外,还列出了一些通过草药治愈伤口的专利。
更新日期:2024-02-04
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