: The [4+2] Diels-Alder cycloaddition has been widely used for the synthesis of six-mem-ber scaffolds. In recent years, there have been significant developments in this area, including the discovery and design of novel dienes and dienophiles with improved reactivity and selectivity. These new building blocks can be used to develop diverse molecular structures with functional group compatibility. Additionally, there is the use of catalytic systems and metal-mediated reactions to enable asymmetric [4+2] cycloadditions, resulting in enantiomerically enriched products. Over-all, recent studies related to [4+2] Diels-Alder cycloaddition using numerous dienes, dienophiles, and catalysts in different reaction conditions have significantly improved the efficiency, selectivity, and versatility of the reaction, making it an increasingly important tool in the synthesis of complex organic molecules as presented in this review. These advancements offer exciting possibilities for the development of new methods and reagents for the construction of six-membered rings and the synthesis of bioactive compounds.

中文翻译：

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狄尔斯-阿尔德反应最新进展简述

: [4+2] Diels-Alder 环加成反应已广泛用于六元支架的合成。近年来，该领域取得了重大进展，包括发现和设计了具有改进的反应性和选择性的新型二烯和亲二烯体。这些新的构建模块可用于开发具有官能团兼容性的多种分子结构。此外，还使用催化系统和金属介导的反应来实现不对称[4+2]环加成，从而产生对映体富集的产物。总的来说，最近与在不同反应条件下使用多种二烯、亲二烯体和催化剂的[4+2]狄尔斯-阿尔德环加成相关的研究显着提高了反应的效率、选择性和多功能性，使其成为越来越重要的工具。本综述中介绍的复杂有机分子的合成。这些进步为开发用于构建六元环和合成生物活性化合物的新方法和试剂提供了令人兴奋的可能性。