: Inflammatory bowel disease (IBD) is a life-threatening complex disease. It causes chronic intestinal inflammation in GIT. IBD significantly affects people’s lifestyles and carries a high risk of colon cancer. IBD involves the rectum, ileum, and colon, with clinical manifestations of bloody stools, weight loss, diarrhea, and abdominal pain. The prevalence of inflammatory disease is increasing dramatically worldwide. Over 16 million people are affected annually in India, with an economic burden of $6.8- $8.8 billion for treatment. Modern medicine can manage IBD as immunosuppressive agents, corticosteroids, tumor necrosis factor antagonists, integrin blockers, and amino-salicylates. However, these approaches are allied with limitations such as limited efficacy, drug resistance, undesired side effects, and overall cost, which cannot be ignored. Hence, the herbal bioactives derived from various plant resources can be employed in managing IBD. Science Direct, PubMed, Google, and Scopus databases have been searched for conclusively relevant herbal plant-based anti-inflammatory agent compositions. Studies were screened through analysis of previously published review articles. Eminent herbal bioactives, namely curcumin, resveratrol, ellagic acid, silybin, catechin, kaempferol, icariin, glycyrrhizin acid, berberine, quercetin, rutin, and thymol are reported to be effective against IBD. Herbal leads are promising treatment options for IBD; they have been shown to display antiinflammatory and antioxidant properties by targeting enzymes and regulating the expressions of various inflammatory mediators. Natural products have been reported to have anti-inflammatory properties in various clinical and preclinical studies, and some are available as herbal preparations. Herbal medicine would be promising in association with the implication of a novel drug delivery system for managing IBD.

中文翻译：

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最近对基于草药生物活性物质的慢性肠道炎症治疗新方法的见解

：炎症性肠病（IBD）是一种危及生命的复杂疾病。它会导致胃肠道慢性肠道炎症。 IBD 显着影响人们的生活方式，并具有患结肠癌的高风险。 IBD累及直肠、回肠和结肠，临床表现为便血、体重减轻、腹泻和腹痛。炎症性疾病的患病率在世界范围内急剧增加。印度每年有超过 1600 万人受到影响，治疗的经济负担为 6.8 至 88 亿美元。现代医学可以通过免疫抑制剂、皮质类固醇、肿瘤坏死因子拮抗剂、整合素阻滞剂和氨基水杨酸盐​​来治疗 IBD。然而，这些方法都存在一些不容忽视的局限性，例如疗效有限、耐药性、不良副作用和总体成本。因此，源自各种植物资源的草药生物活性物质可用于治疗IBD。 Science Direct、PubMed、Google 和 Scopus 数据库已被搜索以寻找最终相关的草药抗炎剂组合物。通过分析先前发表的评论文章来筛选研究。据报道，著名的草药生物活性物质，即姜黄素、白藜芦醇、鞣花酸、水飞蓟宾、儿茶素、山奈酚、淫羊藿苷、甘草酸、小檗碱、槲皮素、芦丁和百里香酚可有效对抗IBD。草药是 IBD 有前途的治疗选择；它们已被证明通过靶向酶和调节各种炎症介质的表达而表现出抗炎和抗氧化特性。据报道，天然产物在各种临床和临床前研究中具有抗炎特性，其中一些可作为草药制剂使用。草药与治疗炎症性肠病的新型药物输送系统的结合将是有前景的。