The simultaneous determination of trace pesticides in complex matrices containing high concentrations of natural pigments remains challenging. In this study, quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation together with high-performance liquid chromatography with ultraviolet detection (HPLC–UV) was applied for the multi-residue analysis of seven sulfonylurea herbicides (SUHs) in tomatoes. SUH residue was extracted using the QuEChERS procedure, followed by solid-phase extraction (SPE) and dispersive SPE (d-SPE). To reduce the amount of carotenoids in tomato extracts, several d-SPE clean-up procedures were compared, and octadecylsilane (C18) provided the best color removal rate (%) of tomato extracts and recoveries (%) for all the tested SUHs. The validation results indicate good linearity (R2 > 0.9970), accuracy, and precision. Recoveries of 70–120% and relative standard deviations < 20% were achieved for all analytes at three spiked concentrations. The limits of detection and quantification for the 7 SUHs were 0.003 mg kg−1 and 0.008–0.009 mg kg−1, respectively. The developed method was subsequently used to quantify multi-residue SUHs during real sample analysis. None of the tested samples had SUH residue levels higher than the maximum residue limits established by the Korean Ministry of Food and Drug Safety. The results suggest that QuEChERS sample preparation employing a combination of C18 is a high-throughput and rapid clean-up procedure for the multi-residue analysis of SUHs in tomatoes.

中文翻译：

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QuEChERS 方法与 HPLC 联用同时测定番茄中的磺酰脲类除草剂

同时测定含有高浓度天然色素的复杂基质中的痕量农药仍然具有挑战性。在这项研究中，快速、简单、廉价、有效、坚固和安全 (QuEChERS) 样品制备以及高效液相色谱和紫外检测 (HPLC-UV) 应用于七种磺酰脲类除草剂 (SUH) 的多残留分析）在西红柿中。使用 QuEChERS 程序萃取 SUH 残留物，然后进行固相萃取 (SPE) 和分散 SPE (d-SPE)。为了减少番茄提取物中类胡萝卜素的含量，对几种 d-SPE 净化程序进行了比较，十八烷基硅烷 (C18) 为所有测试的 SUH 提供了最佳的番茄提取物颜色去除率 (%) 和回收率 (%)。验证结果表明具有良好的线性度 (R2 > 0.9970)、准确性和精密度。所有分析物在三个加标浓度下均实现了 70-120% 的回收率和 < 20% 的相对标准偏差。 7 个 SUH 的检测限和定量限分别为 0.003 mg kg−1 和 0.008–0.009 mg kg−1。所开发的方法随后用于在实际样品分析过程中量化多残留 SUH。所有测试样品的 SUH 残留水平均高于韩国食品药品安全部规定的最大残留限量。结果表明，采用 C18 组合进行 QuEChERS 样品制备是一种高通量、快速净化程序，适用于番茄中 SUH 的多残留分析。