Due to antibiotic overuse, numerous organisms have evolved multidrug resistance, a global health crisis. Klebsiella pneumoniae (K. pneumoniae) causes respiratory, biliary, and urinary infections. It initially impacts individuals with impaired immune systems. The treatment of K. pneumoniae clones poses significant challenges, highlighting the need for new, more effective pathogen control methods. Our understanding of the natural or acquired antibiotic resistance mechanisms in K. pneumoniae is inadequate. Therefore, it is crucial to continue searching for novel compounds to fight against K. pneumoniae and to understand its antibiotic resistance processes fully. This review covers K. pneumoniae antibiotic resistance in detail. The review also identifies the molecular components of natural or acquired K. pneumoniae antibiotic resistance mechanisms. This study further digs into the novel pharmacological targets to offer therapy insights.

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克服肺炎克雷伯菌抗生素耐药性：机制和药物发现的新见解

由于抗生素的过度使用，许多生物体已经产生了多重耐药性，这是一场全球健康危机。肺炎克雷伯菌（K.pneumoniae）引起呼吸道、胆道和泌尿道感染。它最初会影响免疫系统受损的个体。肺炎克雷伯菌克隆的治疗提出了重大挑战，凸显了对新的、更有效的病原体控制方法的需求。我们对肺炎克雷伯菌天然或获得性抗生素耐药机制的了解还不够。因此，继续寻找新的化合物来对抗肺炎克雷伯菌并充分了解其抗生素耐药过程至关重要。本综述详细介绍了肺炎克雷伯菌抗生素耐药性。该综述还确定了天然或获得性肺炎克雷伯菌抗生素耐药机制的分子成分。这项研究进一步深入研究了新的药理学靶点，以提供治疗见解。