Abstract

The molecular mechanisms of the interaction of anticancer antibiotic doxorubicin with lipid cell membrane models have been investigated using grazing incidence X-ray diffraction (XRD) and X-ray reflectivity (XRR). The model systems were monolayers of four types of phospholipids, related to the main components of animal cell membranes. New information on the processes of damage of phospholipid monolayer lattice caused by doxorubicin is obtained. It is established that the action of doxorubicin on anionic phospholipid monolayers is determined by the electrostatic interaction: positively charged doxorubicin molecules are incorporated between negatively charged phospholipid functional groups. In the case of neutral phospholipids the key role belongs to the hydrophobic interaction: doxorubicin molecules are coordinated with phospholipid hydrocarbon tails in disordered regions.

中文翻译：

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抗癌抗生素阿霉素引起的细胞膜模型结构重组

摘要

使用掠入射 X 射线衍射 (XRD) 和 X 射线反射率 (XRR) 研究了抗癌抗生素阿霉素与脂质细胞膜模型相互作用的分子机制。该模型系统是四种磷脂的单层，与动物细胞膜的主要成分有关。获得了阿霉素引起的磷脂单层晶格损伤过程的新信息。已确定阿霉素对阴离子磷脂单层的作用是由静电相互作用决定的：带正电荷的阿霉素分子掺入带负电荷的磷脂官能团之间。就中性磷脂而言，关键作用属于疏水相互作用：阿霉素分子与无序区域中的磷脂烃尾部协调。