Background and aims

To evaluate the prognostic significance of preoperative creatine kinase (CK) levels in bladder cancer (BCa) patients who underwent radical cystectomy (RC).

Materials and methods

570 BCa patients with RC were identified between 2010 and 2020. 108.5 U/L of CK levels were defined as the cutoff value. Logistic regression analysis and Cox regression models were performed to evaluate the association between CK levels and oncologic outcomes. Subgroup analyses were performed to address cofounding factors.

Results

Preoperative low CK levels were associated with worse recurrence-free survival (RFS, log-rank P = 0.001) and overall survival (OS, log-rank P = 0.002). Multivariate analysis revealed that preoperative low CK levels were an independent predictor for worse RFS (hazard ratio [HR]: 1.683; P < 0.001) and OS (HR: 1.567; P = 0.002).

Conclusions

The preoperative low CK level independently predicts worse survival outcomes in BCa after RC. Incorporating it into prediction models might be valuable to assist risk stratification.

中文翻译：

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术前低血浆肌酸激酶水平预示膀胱癌根治性膀胱切除术后生存结果较差

背景和目标

评估术前肌酸激酶 (CK) 水平对接受根治性膀胱切除术 (RC) 的膀胱癌 (BCa) 患者的预后意义。

材料和方法

2010 年至 2020 年间，鉴定了 570 名患有 RC 的 BCa 患者。将 108.5 U/L 的 CK 水平定义为截止值。进行 Logistic 回归分析和 Cox 回归模型来评估 CK 水平和肿瘤学结果之间的关联。进行亚组分析以解决共同创立因素。

结果

术前低 CK 水平与较差的无复发生存率（RFS，对数秩P  = 0.001）和总生存率（OS，对数秩P  = 0.002）相关。多变量分析显示，术前低 CK 水平是较差 RFS（风险比 [HR]：1.683；P  < 0.001）和 OS（HR：1.567；P  = 0.002）的独立预测因素。

结论

术前低 CK 水平独立预测 RC 后 BCa 生存结果较差。将其纳入预测模型可能有助于风险分层。