Purpose

Our study aimed to evaluate the impact of the menstrual cycle stages, especially menses, on sleep, inflammatory mediators, fatigue, anxiety, depression, and quality of life.

Methods

We used data from the EPISONO study cohort, selecting 96 women who had undergone one-night polysomnography. The women were distributed in three groups according to the time point of the menstrual cycle on the polysomnography night: menses, mid/late follicular phase, and luteal phase. The volunteers completed questionnaires related to sleep quality, daytime sleepiness, insomnia, fatigue, anxiety, depression, and quality of life. Blood samples were collected to analyze interleukin 6, tumor necrosis factor-alpha, and C-reactive protein.

Results

Sleep efficiency was statistically higher in women in the mid/late follicular group (89.9% ± 9.6) compared to menstrual (83.0% ± 10.8) and luteal (83.7% ± 12.7) groups. The mid/late follicular group presented a statistically significant reduction in sleep onset latency (7.1 ± 7.1 min) compared to the menstrual (22.3 ± 32.4 min) and luteal groups (15.9 ± 14.7 min). No statistical differences among the three groups were observed in other polysomnographic parameters, inflammatory mediators, daytime sleepiness, insomnia, fatigue, anxiety, depression, and quality of life.

Conclusions

Our findings demonstrate that the mid/late follicular phase might be beneficial for women’s sleep, although there were no statistically changes in inflammatory mediators among the groups.

中文翻译：

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月经周期的各个阶段如何影响睡眠？ EPISONO 数据库的多导睡眠图研究

目的

我们的研究旨在评估月经周期阶段，尤其是月经，对睡眠、炎症介质、疲劳、焦虑、抑郁和生活质量的影响。

方法

我们使用 EPISONO 研究队列的数据，选择了 96 名接受过一晚多导睡眠图检查的女性。根据多导睡眠图夜间的月经周期时间点，将女性分为三组：月经期、卵泡期中/晚期和黄体期。志愿者完成了与睡眠质量、白天嗜睡、失眠、疲劳、焦虑、抑郁和生活质量相关的调查问卷。收集血样以分析白细胞介素 6、肿瘤坏死因子-α 和 C 反应蛋白。

结果

与月经组（83.0%±10.8）和黄体组（83.7%±12.7）相比，卵泡中/晚期组的女性睡眠效率（89.9%±9.6）更高。与月经组（22.3±32.4 分钟）和黄体组（15.9±14.7 分钟）相比，卵泡中/晚期组的睡眠潜伏期（7.1±7.1 分钟）显着缩短。三组在其他多导睡眠图参数、炎症介质、日间嗜睡、失眠、疲劳、焦虑、抑郁和生活质量方面未观察到统计学差异。

结论

我们的研究结果表明，卵泡中/晚期可能有利于女性的睡眠，尽管各组之间的炎症介质没有统计学变化。