Abstract

The reaction of bisisatins containing a 1,ω-alkylene, -arylene, or -alkyluracil spacer with ammonium acetohydrazides gave a series of symmetric and asymmetric dicationic isatin-3-acylhydrazones. It was shown that the antimicrobial activity of the new compounds depends on the structure of the spacer and the nature of the substituent in the aromatic fragment. 5-Substituted isatin derivatives, where the heterocyclic fragments are linked by an 9- and 10-carbon alkylene chains, exhibit bactericidal effect against resistant strains of S. aureus at the level of Norfloxacin and the fungal pathogen P. cactorum, which causes plant late blight.

中文翻译：

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生物活性对称和不对称双阳离子双（靛红腙）：哪个更好——使间隔基复杂化或简化？

摘要

含有1,ω-亚烷基、-亚芳基或-烷基尿嘧啶间隔基的二靛红与乙酰肼铵反应得到一系列对称和不对称的二价靛红-3-酰腙。结果表明，新化合物的抗菌活性取决于间隔基的结构和芳香片段中取代基的性质。 5-取代靛红衍生物，其中杂环片段通过 9 碳和 10 碳亚烷基链连接，在诺氟沙星水平上对金黄色葡萄球菌耐药菌株和导致植物晚熟的真菌病原体P. cactorum表现出杀菌作用。枯萎病。