Abstract

The sulfa-Michael/aldol cascade reaction of (Z)-2-(arylmethylene)-5,6-dihydroimidazo[2,1-b]thiazol-3(2H)-ones and 1,4-dithiane-2,5-diol afforded novel 2'-aryl-4'-hydroxy-4',5,5',6-tetrahydro-2'H,3H-spiro[imidazo[2,1-b]thiazole-2,3'-thiophen]-3-ones in moderate yields. The structures of all the products were characterized thoroughly by IR and NMR spectroscopy and HRMS, as well as XRD analysis.

中文翻译：

---

通过磺胺-迈克尔/羟醛级联反应合成螺[咪唑并[2,1-b]噻唑-2,3'-噻吩]

摘要

( Z )-2-(芳基亚甲基)-5,6-二氢咪唑并[2,1- b ]噻唑-3( 2H )-酮与1,4-二噻烷-2,5的磺胺-迈克尔/羟醛级联反应-二醇提供了新型2'-芳基-4'-羟基-4',5,5',6-四氢-2'H , 3H-螺[咪唑并[2,1- b ]噻唑-2,3'-噻吩]-3-酮，产率中等。所有产品的结构均通过红外光谱、核磁共振光谱、HRMS 以及 XRD 分析进行了彻底表征。