The effect of thioxypine (2-ethyl-6-methylpyridinol-3-yl thioctate) and its acyl and alcohol components on the duration of behavioral despair (BD) in the mouse tail suspension test according to L. Steru, et al. and the forced swimming test of mice and rats according to R. Porsolt, et al. was studied. Amitriptyline (a reference antidepressant) was used as a reference BD-contractor. The impact of the substances being studied on the behavior of mice in the open-field test was additionally evaluated to provide a control of false-positive and false-negative results. Ambiguous effects of the studied substances on the duration of BD were revealed. The direction of the changes depended on the stress generated in the used tests. Thioxypine, unlike its free components, was shown to lack thymoanaleptic potential although it had a sedative effect due to its acyl (thioctyl) fragment. The prospects of further studying the psychotropic action of thioxypine with an emphasis on identification of its possible tranquilizing and antipsychotic activity were considered.

根据 L. Steru 等人的研究，硫氧平（2-乙基-6-甲基吡啶醇-3-基硫辛酸酯）及其酰基和醇成分对小鼠悬尾试验中行为绝望 (BD) 持续时间的影响。以及根据 R. Porsolt 等人的小鼠和大鼠的强迫游泳测试。被研究了。阿米替林（一种参考抗抑郁药）被用作参考 BD 承包商。另外还评估了所研究的物质对旷场测试中小鼠行为的影响，以控制假阳性和假阴性结果。研究揭示了所研究的物质对 BD 持续时间的模糊影响。变化的方向取决于所使用的测试中产生的应力。与其游离成分不同，硫氧平被证明缺乏胸腺兴奋潜力，尽管它由于其酰基（硫辛基）片段而具有镇静作用。考虑了进一步研究硫氧平的精神治疗作用的前景，重点是确定其可能的镇静和抗精神病活性。