Macrophages must remove apoptotic cells to shield tissues from the deleterious components of dying cells. The development of chronic inflammation and autoimmune symptoms in systemic lupus is influenced by a deficiency in phagocytosis of apoptotic cells but the underlying mechanism is still unknown. Modifications in monocyte/macrophage phenotype brought on by an increase in their inflammatory phenotype would cause them to decrease the expression of CPT1a, which would reduce their ability to phagocytose, aggravating kidney damage in lupus nephritis. We aim to demonstrate that the deficiency of CPT1A in the immunological system determines lupus.

中文翻译：

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狼疮性肾炎的吞噬功能障碍与单核/巨噬细胞CPT1a有关

巨噬细胞必须清除凋亡细胞，以保护组织免受垂死细胞的有害成分的影响。系统性狼疮慢性炎症和自身免疫症状的发展受到凋亡细胞吞噬作用缺陷的影响，但其潜在机制仍不清楚。炎症表型增加引起的单核细胞/巨噬细胞表型改变会导致它们 CPT1a 的表达减少，从而降低它们的吞噬能力，​​从而加重狼疮性肾炎的肾脏损害。我们的目的是证明免疫系统中 CPT1A 的缺乏决定了狼疮。