Chronic and neurotropic: A paradigm-challenging case of dengue virus encephalitis in patient with advanced human immunodeficiency virus infection,Clinical Infectious Diseases

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Chronic and neurotropic: A paradigm-challenging case of dengue virus encephalitis in patient with advanced human immunodeficiency virus infection
Clinical Infectious Diseases ( IF 11.8 ) Pub Date : 2024-02-06 , DOI: 10.1093/cid/ciae061
Tina Marinelli ₁ , Jeffrey Masters _{1,

2} , Michael E Buckland _{3,

4} , Maggie Lee ₃ , William Rawlinson _{5,

6} , Ki Wook Kim ₆ , Nicolas Urriola ₇ , Sebastiaan van Hal ₁

Affiliation

A 32-year-old female with advanced HIV infection presented to an Australian hospital with subacute but worsening symptoms of encephalitis. Metagenomic sequencing and Dengue NS3 antigen staining of brain tissue confirmed active Dengue virus (DENV) encephalitis. The most recent possible DENV exposure was months prior in West Africa, indicating chronicity.

中文翻译：

慢性和神经营养性：晚期人类免疫缺陷病毒感染患者登革热病毒脑炎的典型挑战病例

一名 32 岁女性艾滋病毒感染晚期，因亚急性脑炎症状但病情不断恶化而到澳大利亚一家医院就诊。脑组织的宏基因组测序和登革热 NS3 抗原染色证实了活动性登革热病毒 (DENV) 脑炎。最近一次可能的登革热病毒暴露发生在几个月前，发生在西非，这表明该病毒是长期暴露的。

更新日期：2024-02-06

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