Background: One of the most researched issues is the elimination of uremic toxins from the human body. These toxins can build up and lead to catastrophic issues including renal failure. To get rid of them, absorbents like activated carbon, zeolites, and other minerals are frequently utilized. Methods: Mesoporous silica nanoparticles functionalized with (3-Aminopropyl) triethox-ysilane (APTES) linker (MSN-NH2) and mesoporous silica nanoparticles grafted with molec-ularly imprinted polymers (MSN-MIP) from the previous study were examined in this study to determine how well they absorbed urea, creatinine, and uric acid in a simulated intestinal serum. Results: MSN-MIP's large surface area (879.12 (m2/g)) and volume of pores (0.8475 (cm3/g)) made removal results that were satisfactory in the simulated serum. Additionally, MSN-MIP demonstrated a high urea adsorption capacity (qm = 1836.45 mg/g). Creatinine (qm = 1529.5 mg/g) and uric acid (qm = 1210.6 mg/g) were absorbed via NH-MSN2, which demonstrated a noticeable potential for absorption. The results of cell viability test for the first 72 hours, showed that the use of these absorbents in hemodialysis systems is acceptable. Conclusion: Synthesized adsorbents can be utilized in the hemodialysis system since the results of the cell viability test also showed that the percentage of cell viability was extremely high up to 72 hours.

中文翻译：

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用介孔二氧化硅纳米颗粒与分子印迹聚合物和氨基连接体结合消除模拟肠血清中的尿毒症毒素

背景：研究最多的问题之一是消除人体内的尿毒症毒素。这些毒素会积聚并导致灾难性问题，包括肾衰竭。为了去除它们，经常使用活性炭、沸石和其他矿物质等吸收剂。方法：本研究检查了先前研究中用（3-氨基丙基）三乙氧基硅烷（APTES）连接剂（MSN-NH2）功能化的介孔二氧化硅纳米粒子和接枝有分子印迹聚合物的介孔二氧化硅纳米粒子（MSN-MIP）确定他们在模拟肠道血清中吸收尿素、肌酐和尿酸的情况。结果：MSN-MIP的较大比表面积（879.12（m2/g））和孔体积（0.8475（cm3/g））在模拟血清中取得了令人满意的去除效果。此外，MSN-MIP 表现出较高的尿素吸附能力 (qm = 1836.45 mg/g)。肌酐 (qm = 1529.5 mg/g) 和尿酸 (qm = 1210.6 mg/g) 通过 NH-MSN2 被吸收，这表明具有显着的吸收潜力。前 72 小时的细胞活力测试结果表明，这些吸收剂在血液透析系统中的使用是可以接受的。结论：合成吸附剂可用于血液透析系统，因为细胞活力测试的结果也表明细胞活力百分比极高，长达72小时。