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Discovery of new thymol-3,4-disubstituted thiazole hybrids as dual COX-2/5-LOX inhibitors with in vivo proof
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-01-30 , DOI: 10.1080/14756366.2024.2309171 Mostafa M. M. El-Miligy 1 , Ahmed K. Al-Kubeisi 2 , Rasha A. Nassra 3 , Saad R. El-Zemity 4 , Aly A. Hazzaa 1
Journal of Enzyme inhibition and Medicinal Chemistry ( IF 5.6 ) Pub Date : 2024-01-30 , DOI: 10.1080/14756366.2024.2309171 Mostafa M. M. El-Miligy 1 , Ahmed K. Al-Kubeisi 2 , Rasha A. Nassra 3 , Saad R. El-Zemity 4 , Aly A. Hazzaa 1
Affiliation
New thymol–3,4-disubstitutedthiazole hybrids were synthesised as dual COX-2/5-LOX inhibitors. Compounds 6b, 6d, 6e, and 6f displayed in vitro inhibitory activity against COX-2 (IC50= 0.037, 0.042, ...
中文翻译：
发现新的百里酚-3,4-二取代噻唑杂化物作为双重 COX-2/5-LOX 抑制剂并具有体内证据
合成了新的百里酚-3,4-二取代噻唑杂化物作为双重 COX-2/5-LOX 抑制剂。化合物 6b、6d、6e 和 6f 显示出针对 COX-2 的体外抑制活性（IC50= 0.037、0.042，...
更新日期：2024-01-30
中文翻译：
发现新的百里酚-3,4-二取代噻唑杂化物作为双重 COX-2/5-LOX 抑制剂并具有体内证据
合成了新的百里酚-3,4-二取代噻唑杂化物作为双重 COX-2/5-LOX 抑制剂。化合物 6b、6d、6e 和 6f 显示出针对 COX-2 的体外抑制活性（IC50= 0.037、0.042，...
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