Background: Migraine is implicated in oxidative stress. The oxidative balance score (OBS) assesses the combined impact of diet and lifestyle on oxidative and antioxidant balance in diseases. However, the association between OBS and migraine remains underexplored. Objective: We aimed to examine the relationship between OBS and severe headaches or migraines among American adults. Methods: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) 1999-2004, defining severe headaches or migraine via self-reports and calculating OBS from 16 diaries and 4 lifestyle factors. Multivariable weighted logistic regression models were used to explore the OBS-migraine relationship, with stratified analysis for result validation. Results: The study included 6,653 participants (average age 45.6, 52.1% male), and 19.1% reported severe headaches or migraines. There was a significant inverse association between OBS and severe headache or migraine, with an adjusted odds ratio (OR) of 0.97 (95% [confidence interval] CI: 0.96, 0.98, p < 0.001). The highest OBS tertile had an adjusted OR of 0.58 (95% CI: 0.47, 0.73) compared to the lowest. This pattern was consistent across sexes, with an adjusted OR of 0.98 (0.95, 1.00) in males and 0.97 (0.95, 1.00) in females. The adjusted OR for migraine was 0.61 (0.44, 0.87) and 0.54 (0.37, 0.79) in the highest tertile for males and females, respectively.

中文翻译：

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美国成年人氧化平衡评分与严重头痛或偏头痛之间的关联横断面研究

背景：偏头痛与氧化应激有关。氧化平衡评分（OBS）评估饮食和生活方式对疾病中氧化和抗氧化平衡的综合影响。然而，OBS 与偏头痛之间的关联仍未得到充分研究。目的：我们旨在研究美国成年人中 OBS 与严重头痛或偏头痛之间的关系。方法：这项横断面研究利用了 1999-2004 年国家健康和营养检查调查 (NHANES) 的数据，通过自我报告定义严重头痛或偏头痛，并根据 16 份日记和 4 个生活方式因素计算 OBS。使用多变量加权逻辑回归模型来探讨 OBS 与偏头痛的关系，并通过分层分析来验证结果。结果：该研究共有 6,653 名参与者（平均年龄 45.6 岁，52.1% 为男性），其中 19.1% 报告有严重头痛或偏头痛。 OBS 与严重头痛或偏头痛之间存在显着的负相关，调整后的比值比 (OR) 为 0.97（95% [置信区间] CI：0.96、0.98，p < 0.001）。与最低 OBS 三分位数相比，最高 OBS 三分位数的调整 OR 为 0.58（95% CI：0.47，0.73）。这种模式在不同性别中是一致的，男性的调整 OR 为 0.98 (0.95, 1.00)，女性的调整 OR 为 0.97 (0.95, 1.00)。男性和女性最高三分位偏头痛的调整后 OR 分别为 0.61 (0.44, 0.87) 和 0.54 (0.37, 0.79)。