There are a lot of temperature-sensitive proteins including transient receptor potential (TRP) channels. Some TRP channels are temperature receptors having specific activation temperatures in vitro that are within the physiological temperature range. Mice deficient in specific TRP channels show abnormal thermal behaviors, but the role of TRP channels in these behaviors is not fully understood. The Thermal Gradient Ring is a new apparatus that allows mice to freely move around the ring floor and not stay in a corner. The system can analyze various factors (e.g., ‘Spent time’, ‘Travel distance’, ‘Moving speed’, ‘Acceleration’) associated with temperature-dependent behaviors of TRP-deficient mice. For example, the Ring system clearly discriminated differences in temperature-dependent phenotypes between mice with diabetic peripheral neuropathy and TRPV1−/− mice, and demonstrated the importance of TRPV3 in temperature detection in skin. Studies using the Thermal Gradient Ring system can increase understanding of the molecular basis of thermal behaviors in mice and in turn help develop strategies to affect responses to different temperature conditions in humans.

中文翻译：

---

用于分析涉及小鼠 TRP 通道的温度依赖性行为的热梯度环

有许多温度敏感蛋白，包括瞬时受体电位（TRP）通道。一些TRP通道是温度受体，在体外具有在生理温度范围内的特定激活温度。缺乏特定 TRP 通道的小鼠表现出异常的热行为，但 TRP 通道在这些行为中的作用尚不完全清楚。热梯度环是一种新装置，可以让小鼠在环地板上自由移动，而不是呆在角落里。该系统可以分析与 TRP 缺陷小鼠的温度依赖性行为相关的各种因素（例如，“花费时间”、“行进距离”、“移动速度”、“加速度”）。例如，Ring系统清楚地区分了糖尿病周围神经病变小鼠和TRPV1−/−小鼠之间温度依赖性表型的差异，并证明了TRPV3在皮肤温度检测中的重要性。使用热梯度环系统的研究可以增进对小鼠热行为分子基础的理解，进而有助于制定影响人类对不同温度条件的反应的策略。