A protein-templated selection approach has been developed for the discovery of full ligands from dual-pharmacophore DNA-encoded libraries by incorporating fragment linking into the selection process. The performance of this method was demonstrated with selections against protein–protein interaction and protein–DNA interaction targets, through which potent and selective inhibitors were identified.

中文翻译：

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用于从 DNA 编码文库中鉴定完整配体的蛋白质模板选择方法

已经开发出一种蛋白质模板选择方法，通过将片段连接纳入选择过程，从双药效团 DNA 编码文库中发现完整配体。该方法的性能通过针对蛋白质-蛋白质相互作用和蛋白质-DNA 相互作用靶标的选择来证明，通过这些靶标鉴定出有效的选择性抑制剂。