Abstract

Studies of the concentration of iron and molybdenum in the immune-privileged organs of rats without a pathology and after simulating posthemorrhagic anemia, which received intramuscular injections of Keplerate-type nanocluster porous spherical polyoxometalate (POM) {Mo₇₂Fe₃₀}, are conducted. The blood–testis barrier is the most resistant to the penetration of the components of POM, the blood–brain and blood–ocular barriers possess a lower resistance (accumulation of iron after 30 injections of POM), and the blood–thymus barrier is the least resistant. The borrowing of iron from immune-privileged organs such as the brain, eyeballs, and thymus occurs in the early stages (1 to 7 days) of posthemorrhagic anemia. Posthemorrhagic anemia decreases the resistance of the blood–brain barrier and is accompanied by the excessive accumulation of iron after seven injections of POM.

中文翻译：

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纳米簇多孔球形开普勒酸盐型多金属氧酸盐 {Mo72Fe30} 给药后大鼠免疫特权器官中铁和钼的含量

摘要

对没有病理的大鼠和模拟失血后贫血的免疫豁免器官中铁和钼的浓度进行了研究，这些大鼠接受了开普勒酸盐型纳米团簇多孔球形多金属氧酸盐（POM）{Mo 72 _Fe 30 _}的肌内注射。血-睾丸屏障对POM成分渗透的抵抗力最强，血-脑和血-眼屏障的抵抗力较低（注射30次POM后铁积累），血-胸腺屏障是最能抵抗POM成分渗透的屏障。最没有抵抗力。从大脑、眼球和胸腺等免疫特权器官借铁发生在失血后贫血的早期阶段（1 至 7 天）。注射七次 POM 后，血脑屏障的抵抗力降低，并伴有铁的过量积累，导致失血后贫血。