Abstract

The results of the synthesis of a biologically active nanostructured polymer system based on natural κ-carrageenan polysaccharide, which simultaneously acts as a reducing and stabilizing agent for emerging gold nanoparticles, are presented. The structure and nanomorphological characteristics of the resulting nanocomposite (in particular, in an aqueous solution), represented by κ-carrageenan stabilized Au⁰ nanoparticles, the size of which varies in the range of 6–20 nm, are established using modern spectral (infrared and optical spectroscopy, dynamic light scattering) and microscopic (transmission electron microscopy) methods. It is for the first time established that the Au⁰NP/κ-CG-DP nanocomposite has pronounced anticoagulant activity, affecting the intrinsic and extrinsic blood-coagulation pathways.

中文翻译：

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基于硫酸化卡拉胶多糖的含金纳米复合材料的生物活性研究

摘要

介绍了基于天然 κ-卡拉胶多糖的生物活性纳米结构聚合物系统的合成结果，该聚合物系统同时充当新兴金纳米颗粒的还原剂和稳定剂。所得纳米复合材料（特别是在水溶液中）的结构和纳米形态特征，以 κ-卡拉胶稳定的 Au ⁰纳米粒子为代表，其尺寸在 6–20 nm 范围内变化，使用现代光谱（红外光谱）建立和光谱法、动态光散射）和显微（透射电子显微镜）方法。首次证实Au ⁰ NP/κ-CG-DP纳米复合材料具有显着的抗凝血活性，影响内在和外在凝血途径。