Cold atmospheric plasma (CAP) is a novel technology that generates a unique combination of reactive oxygen and nitrogen species (ROS/RNS), electric fields, and UV radiation. CAP has shown promise in regulating the immune system and has potential clinical applications in wound healing, cancer treatment, and infection control. This review provides an overview of the immunological regulation activity of CAP, highlighting its substantial impact on cytokines production, immune cell phagocytosis, and immune cell proliferation. CAP has also been demonstrated to have potent therapeutic effect in anti-inflammation, wound repair, viral and bacterial infections. Furthermore, CAP has been investigated as an adjuvant therapy for tumor treatment, eliciting a robust antitumor immune response and remarkable synergistic effects in diverse combination therapies. Further research is needed to fully understand the mechanisms underlying the effects of CAP on the immune system and to optimize its clinical application.

中文翻译：

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冷大气血浆：一种新兴的免疫调节疗法

冷大气等离子体 (CAP) 是一项新技术，可产生活性氧和氮物质 (ROS/RNS)、电场和紫外线辐射的独特组合。 CAP 在调节免疫系统方面显示出前景，并在伤口愈合、癌症治疗和感染控制方面具有潜在的临床应用。本综述概述了 CAP 的免疫调节活性，强调其对细胞因子产生、免疫细胞吞噬作用和免疫细胞增殖的重大影响。 CAP 还被证明在抗炎、伤口修复、病毒和细菌感染方面具有有效的治疗作用。此外，CAP 已被研究作为肿瘤治疗的辅助疗法，在多种联合疗法中引发强大的抗肿瘤免疫反应和显着的协同效应。需要进一步的研究来充分了解 CAP 对免疫系统影响的机制并优化其临床应用。