当前位置：
X-MOL 学术
›
J. Extracell. Vesicles
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
Journal of Extracellular Vesicles ( IF 16.0 ) Pub Date : 2024-02-07 , DOI: 10.1002/jev2.12404 Joshua A. Welsh 1 , Deborah C. I. Goberdhan 2 , Lorraine O'Driscoll 3, 4, 5 , Edit I. Buzas 6, 7, 8 , Cherie Blenkiron 9 , Benedetta Bussolati 10 , Houjian Cai 11 , Dolores Di Vizio 12 , Tom A. P. Driedonks 13 , Uta Erdbrügger 14 , Juan M. Falcon‐Perez 15, 16, 17 , Qing‐Ling Fu 18, 19 , Andrew F. Hill 20 , Metka Lenassi 21 , Sai Kiang Lim 22, 23, 24 , Mỹ G. Mahoney 25 , Sujata Mohanty 26 , Andreas Möller 27, 28 , Rienk Nieuwland 29, 30 , Takahiro Ochiya 31 , Susmita Sahoo 32 , Ana C. Torrecilhas 33 , Lei Zheng 34 , Andries Zijlstra 35, 36 , Sarah Abuelreich 37 , Reem Bagabas 37 , Paolo Bergese 38, 39, 40 , Esther M. Bridges 41 , Marco Brucale 42, 43 , Dylan Burger 44, 45, 46 , Randy P. Carney 47 , Emanuele Cocucci 48, 49 , Federico Colombo 48 , Rossella Crescitelli 50, 51 , Edveena Hanser 52, 53 , Adrian L. Harris 54 , Norman J. Haughey 55 , An Hendrix 56, 57 , Alexander R. Ivanov 58 , Tijana Jovanovic‐Talisman 59 , Nicole A. Kruh‐Garcia 60 , Vroniqa Ku'ulei‐Lyn Faustino 37 , Diego Kyburz 53, 61 , Cecilia Lässer 62 , Kathleen M. Lennon 37 , Jan Lötvall 63 , Adam L. Maddox 37 , Elena S. Martens‐Uzunova 64 , Rachel R. Mizenko 47 , Lauren A. Newman 65 , Andrea Ridolfi 66 , Eva Rohde 67, 68, 69 , Tatu Rojalin 47, 70 , Andrew Rowland 65 , Andras Saftics 37 , Ursula S. Sandau 71 , Julie A. Saugstad 71 , Faezeh Shekari 72, 73 , Simon Swift 74 , Dmitry Ter‐Ovanesyan 75 , Juan P. Tosar 76, 77 , Zivile Useckaite 65 , Francesco Valle 42, 43 , Zoltan Varga 78, 79 , Edwin van der Pol 30, 80, 81 , Martijn J. C. van Herwijnen 82 , Marca H. M. Wauben 82 , Ann M. Wehman 83 , Sarah Williams 84 , Andrea Zendrini 38, 39 , Alan J. Zimmerman 58 , MISEV Consortium , Clotilde Théry 85, 86 , Kenneth W. Witwer 87, 88, 89
Journal of Extracellular Vesicles ( IF 16.0 ) Pub Date : 2024-02-07 , DOI: 10.1002/jev2.12404 Joshua A. Welsh 1 , Deborah C. I. Goberdhan 2 , Lorraine O'Driscoll 3, 4, 5 , Edit I. Buzas 6, 7, 8 , Cherie Blenkiron 9 , Benedetta Bussolati 10 , Houjian Cai 11 , Dolores Di Vizio 12 , Tom A. P. Driedonks 13 , Uta Erdbrügger 14 , Juan M. Falcon‐Perez 15, 16, 17 , Qing‐Ling Fu 18, 19 , Andrew F. Hill 20 , Metka Lenassi 21 , Sai Kiang Lim 22, 23, 24 , Mỹ G. Mahoney 25 , Sujata Mohanty 26 , Andreas Möller 27, 28 , Rienk Nieuwland 29, 30 , Takahiro Ochiya 31 , Susmita Sahoo 32 , Ana C. Torrecilhas 33 , Lei Zheng 34 , Andries Zijlstra 35, 36 , Sarah Abuelreich 37 , Reem Bagabas 37 , Paolo Bergese 38, 39, 40 , Esther M. Bridges 41 , Marco Brucale 42, 43 , Dylan Burger 44, 45, 46 , Randy P. Carney 47 , Emanuele Cocucci 48, 49 , Federico Colombo 48 , Rossella Crescitelli 50, 51 , Edveena Hanser 52, 53 , Adrian L. Harris 54 , Norman J. Haughey 55 , An Hendrix 56, 57 , Alexander R. Ivanov 58 , Tijana Jovanovic‐Talisman 59 , Nicole A. Kruh‐Garcia 60 , Vroniqa Ku'ulei‐Lyn Faustino 37 , Diego Kyburz 53, 61 , Cecilia Lässer 62 , Kathleen M. Lennon 37 , Jan Lötvall 63 , Adam L. Maddox 37 , Elena S. Martens‐Uzunova 64 , Rachel R. Mizenko 47 , Lauren A. Newman 65 , Andrea Ridolfi 66 , Eva Rohde 67, 68, 69 , Tatu Rojalin 47, 70 , Andrew Rowland 65 , Andras Saftics 37 , Ursula S. Sandau 71 , Julie A. Saugstad 71 , Faezeh Shekari 72, 73 , Simon Swift 74 , Dmitry Ter‐Ovanesyan 75 , Juan P. Tosar 76, 77 , Zivile Useckaite 65 , Francesco Valle 42, 43 , Zoltan Varga 78, 79 , Edwin van der Pol 30, 80, 81 , Martijn J. C. van Herwijnen 82 , Marca H. M. Wauben 82 , Ann M. Wehman 83 , Sarah Williams 84 , Andrea Zendrini 38, 39 , Alan J. Zimmerman 58 , MISEV Consortium , Clotilde Théry 85, 86 , Kenneth W. Witwer 87, 88, 89
Affiliation
Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.
更新日期：2024-02-09
京公网安备 11010802027423号