: Osteoporosis and other bone diseases are a major public health concern worldwide. Current pharmaceutical treatments for bone disorders have limitations, driving interest in complementary herbal medicines that can help maintain bone health. This review summarizes the scientific evidence for medicinal herbs that modulate bone cell activity and improve bone mass, quality and strength. Herbs with osteogenic, anti-osteoporotic, and anti-osteoclastic effects are discussed, including compounds and mechanisms of action. Additionally, this review examines the challenges and future directions for translational research on herbal medicines for osteoporosis and bone health. While preliminary research indicates beneficial bone bioactivities for various herbs, rigorous clinical trials are still needed to verify therapeutic efficacy and safety. Further studies should also elucidate synergistic combinations, bioavailability of active phytochemicals, and precision approaches to match optimal herbs with specific etiologies of bone disease. Advancing evidence- based herbal medicines may provide novel alternatives for promoting bone homeostasis and treating skeletal disorders.

中文翻译：

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草药在调节骨稳态中的作用

：骨质疏松症和其他骨病是全世界主要的公共卫生问题。目前治疗骨骼疾病的药物治疗存在局限性，这引发了人们对有助于维持骨骼健康的补充草药的兴趣。这篇综述总结了调节骨细胞活性和改善骨量、质量和强度的草药的科学证据。讨论了具有成骨、抗骨质疏松和抗破骨作用的草药，包括化合物和作用机制。此外，这篇综述还探讨了用于骨质疏松症和骨骼健康的草药转化研究的挑战和未来方向。虽然初步研究表明各种草药对骨骼有益的生物活性，但仍需要严格的临床试验来验证治疗效果和安全性。进一步的研究还应阐明活性植物化学物质的协同组合、生物利用度，以及将最佳草药与骨病特定病因相匹配的精确方法。推进循证草药可能为促进骨稳态和治疗骨骼疾病提供新的替代方案。