This study investigated the hepatoprotective effects of Juncus effusus (J. effusus) and Carbonized J. effusus against liver injury caused by D-galactosamine (D-GalN) in mice. J. effusus and Carbonized J. effusus were administered by gavage once daily starting seven days before the D-GalN treatment. The results of the study indicated that J. effusus and Carbonized J. effusus suppressed the D-GalN-induced generation of serum alanine transaminase (ALT), aspartate aminotransferase (AST), hepatic malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) was observed. The values of superoxide dismutase (SOD) exhibited an increase. In addition, J. effusus and Carbonized J. effusus promoted the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), NADPH quinone oxidoreductase-1 (NQO-1), heme oxygenase-1 (HO-1) as well as the mRNA expression of Nrf2, HO-1, NQO-1 and Glutamate cysteine ligase catalytic subunit (GCLC). The compressed Carbonized J. effusus demonstrated the optimum impact. These results suggest that J. effusus and Carbonized J. effusus protect against D-GalN-induced acute liver injury through the activation of the Nrf2 pathway.

本研究探讨了灯心草( J. effusus ) 和碳化J. effusus对 D-半乳糖胺 (D-GalN) 引起的小鼠肝损伤的保肝作用。从 D-GalN 治疗前 7 天开始，每天一次通过管饲法施用J. effusus和碳化J. effusus 。研究结果表明，J. effusus和 Carbonized J. effusus抑制 D-GalN 诱导的血清丙氨酸转氨酶 (ALT)、天冬氨酸转氨酶 (AST)、肝丙二醛 (MDA) 和肿瘤坏死因子-α (TNF) 的产生观察到-α)。超氧化物歧化酶（SOD）值有所增加。此外，J. effusus和Carbonized J. effusus还促进核因子红细胞2相关因子2（Nrf2）、NADPH醌氧化还原酶-1（NQO-1）、血红素加氧酶-1（HO-1）的蛋白表达Nrf2、HO-1、NQO-1 和谷氨酸半胱氨酸连接酶催化亚基 (GCLC) 的mRNA表达。压缩的碳化J. effusus表现出最佳的效果。这些结果表明，J. effusus和碳化J. effusus通过激活 Nrf2 途径来防止 D-GalN 诱导的急性肝损伤。