Mitochondrial DNA mutations are present in over 50% of all cancers, and truncating mutations in several genes encoding components of complex I of the respiratory chain are most recurrent. We found that these mutations are a source of Warburg-like metabolic shifts that promote a pro-inflammatory immunological state, enhancing sensitivity to checkpoint blockade.

中文翻译：

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线粒体 DNA 突变增强黑色素瘤免疫治疗的敏感性

超过 50% 的癌症都存在线粒体 DNA 突变，而编码呼吸链复合体 I 成分的多个基因的截短突变最为常见。我们发现这些突变是 Warburg 样代谢变化的来源，可促进促炎免疫状态，增强对检查点封锁的敏感性。