The aim of this review is to present the clinical indications of apolipoprotein C-III (apoC3) inhibition in the therapeutic arsenal for the treatment of lipid disorders and associated risks and to compare the most advanced modalities of apoC3 inhibition currently available or in development, specifically APOC3 antisense oligonucleotides (ASO) and small interfering RNA (siRNA).

中文翻译：

---

APOC3 siRNA 和 ASO 治疗血脂异常。

本综述的目的是介绍载脂蛋白 C-III (apoC3) 抑制在治疗脂质紊乱和相关风险的治疗手段中的临床适应症，并比较目前可用或正在开发的最先进的 apoC3 抑制方式，特别是APOC3 反义寡核苷酸 (ASO) 和小干扰 RNA (siRNA)。