Over the past two decades, cases of sexually transmitted infections (STIs) due to syphilis, gonorrhea, and chlamydia have been rising in the United States, disproportionately among gay, bisexual, and other men who have sex with men (MSM), as well as racial and ethnic minorities of all genders. In this review, we address updates about the evidence on doxycycline post-exposure prophylaxis (doxy-PEP) for prevention of bacterial STIs, including efficacy, safety, antimicrobial resistance (AMR), acceptability, modeling population impact, and evolving guidelines for use. Equitable implementation of doxy-PEP will require evaluation of who is offered and initiates it, understanding patterns of use and longer-term STI incidence and AMR, provider training, and tailored community education.

中文翻译：

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填补空白：多西环素预防细菌性传播感染的最新进展

在过去的二十年里，美国因梅毒、淋病和衣原体引起的性传播感染 (STI) 病例不断增加，其中同性恋、双性恋和其他男男性行为者 (MSM) 的发病率不成比例。作为所有性别的种族和族裔少数群体。在这篇综述中，我们讨论了多西环素暴露后预防 (doxy-PEP) 用于预防细菌性传播感染的最新证据，包括功效、安全性、抗菌素耐药性 (AMR)、可接受性、人群影响建模和不断发展的使用指南。公平实施 doxy-PEP 需要评估提供者和发起者、了解使用模式和长期性传播感染发病率和抗菌素耐药性、提供者培训以及量身定制的社区教育。